in Bradford .
Written in English
Ph.D. thesis. Typescript.
|The Physical Object|
|Number of Pages||425|
The effects of buprenorphine on behaviour in the ACI and BN rat inbred strains H Avsaroglu*, R Sommer*, L J Hellebrekers†,LFMvanZutphen* and H A van Lith* *Department of Animals, Science and Society, Division of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, The Netherlands; †Department of Equine Sciences and Department of Clinical Sciences of Companion. The study, described in this thesis, was undertaken to elucidate the effects predator exposure has on behaviour, on neurochemical parameters in various brain regions and on neuroendocrine parameters. Also the effects of repeated predator exposure were assessed. For this purpose C57bl/6N and Balb/c mice were exposed to a rat for thirty minutes. Borsini F, Podhorna J, Marazziti D () Do animal models of anxiety predict anxiolytic-like effects of antidepressants? Psychopharmacology – CrossRef PubMed Google Scholar Brown SM, Holtzman M, Kim T, Kharasch ED () Buprenorphine metabolites, buprenorphineglucuronide and norbuprenorphineglucuronide, are biologically by: SummaryBuprenorphine is a partial μ, κ agonist that has been shown to influence spontaneous behaviour in animals. Previously, we have demonstrated significant differences in the analgesic response SummaryBuprenorphine is a partial μ, κ agonist that has been shown to influence spontaneous behaviour in animals.
Concerning to grooming behaviour, a symptom closely related with opiate Buprenorphine, antagonist activity abstinence in rats but not in mice, all the animals presented this behaviour after buprenorphine administration ( or 1 mg/kg). Naloxone administration does not induce this behaviour in morphine-dependent mice. The effect of a wide range of doses of buprenorphine (–10 mgkg −1, s.c.), a partial agonist at mu (μ) oipiate receptors, was studied on (a) the steady state levels of dopamine, noradrenaline, 5-hydroxytryptamine, homovanillic acid, 3-methyoxyhydroxyphenylglycol and 5-hydroxyindole acetic acid and (b) the levels of dopamine and noradrenaline in rat brain following . This study examined the effects of chronic MPD treatment during adolescence on emotional and consummatory behaviors in adult spontaneously hypertensive rats (SHRs), often proposed as an animal. However, an increase in plasma corticosterone levels was observed following chronic stress treatment, an effect similar to previous reports in humans [25, 35] and animals [20, 21]. The fact that increased levels of corticosterone were measured one day after treatment suggests that the observed behavioral and neurochemical effects were in fact.
Importantly, while suicidal behavior occurs in the presence of any psychiatric condition, consistent studies repeatedly showed that suicide is most common in subjects with major mood disorders (MDD and bipolar disorder) .In , suicide across all ages entered the top 20 leading causes of death—accounting as the most relevant cause of death for % of all deaths worldwide—and the. Robert N. Pechnick, Robert George, Russell E. Poland, The effects of the acute administration of buprenorphine hydrochloride on the release of anterior pituitary hormones in the rat: Evidence for the involvement of multiple opiate receptors, Life Sciences, /(85), 37, . the removal of duplicates, animal studies, and non-clinical studies, citations remained. Of these, 88 abstracts were screened and 54 full texts were retrieved for review. Twenty-eight articles met the inclusion criteria (Fig. 1). These 28 studies included patients. All studies investigated the Efﬁcacy and adverse effects of. Although once considered a benign recreational stimulant, cocaine is now recognized to possess substantial abuse potential with considerable medical and social consequences. Accordingly, these experiments examined the behavioural and neurobiological effects of cocaine in the rat. The behavioural and neurochemical interactions between cocaine and buprenorphine were examined .